solution that is an inverse problem. Chromatography models are represented by systems of partial differential equations with
non-linear parameters which are, in general, difficult to estimate many times. In this work a genetic algorithm is used to
solve the inverse problem of parameters estimation in a model of protein adsorption by batch chromatography process. Each
population individual represents a supposed condition to the direct solution of the partial differential equation system,
so the computation of the fitness can be time consuming if the population is large. To avoid this difficulty, the implemented
genetic algorithm divides the population into clusters, whose representatives are evaluated, while the fitness of the remaining
individuals is calculated in function of their distances from the representatives. Simulation and practical studies illustrate
the computational time saving of the proposed genetic algorithm and show that it is an effective solution method for this
type of application.
- Content Type Journal Article
- Pages 1-11
- DOI 10.1007/s00500-010-0638-3
- Authors
- Mirtha Irizar Mesa, Technical University of Havana (ISPJAE) Department of Automation and Computers Ciudad de La Habana Cuba
- Orestes Llanes-Santiago, Technical University of Havana (ISPJAE) Department of Automation and Computers Ciudad de La Habana Cuba
- Francisco Herrera Fernández, Central University of Las Villas (UCLV) Department of Automation and Computational Systems Villa Clara Cuba
- David Curbelo Rodríguez, Center of Molecular Immunology Ciudad de la Habana Cuba
- Antônio José Da Silva Neto, IPRJ-UERJ Departamento de Engenharia Mecânica e Energia, DEMEC Nova Friburgo Brazil
- Leôncio Diógenes T. Câmara, IPRJ-UERJ Departamento de Engenharia Mecânica e Energia, DEMEC Nova Friburgo Brazil
- Journal Soft Computing – A Fusion of Foundations, Methodologies and Applications
- Online ISSN 1433-7479
- Print ISSN 1432-7643