Abstract
The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the
minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation,
and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for
the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and
on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock
response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides
a useful foundation for modeling strategies of more complex cellular processes.
minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation,
and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for
the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and
on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock
response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides
a useful foundation for modeling strategies of more complex cellular processes.
- Content Type Journal Article
- DOI 10.1007/s11047-010-9216-y
- Authors
- Ion Petre, Department of Information Technologies, Åbo Akademi University, Turku, 20520 Finland
- Andrzej Mizera, Department of Information Technologies, Åbo Akademi University, Turku, 20520 Finland
- Claire L. Hyder, Turku Centre for Biotechnology, Turku, Finland
- Annika Meinander, Turku Centre for Biotechnology, Turku, Finland
- Andrey Mikhailov, Turku Centre for Biotechnology, Turku, Finland
- Richard I. Morimoto, Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
- Lea Sistonen, Turku Centre for Biotechnology, Turku, Finland
- John E. Eriksson, Turku Centre for Biotechnology, Turku, Finland
- Ralph-Johan Back, Department of Information Technologies, Åbo Akademi University, Turku, 20520 Finland
- Journal Natural Computing
- Online ISSN 1572-9796
- Print ISSN 1567-7818
