Abstract This paper combines a powerful algorithm, called Dongguang Li (DGL) global optimization, with the methods of cancer diagnosis
through gene selection and microarray analysis. A generic approach to cancer classification based on gene…
Abstract This paper combines a powerful algorithm, called Dongguang Li (DGL) global optimization, with the methods of cancer diagnosis
through gene selection and microarray analysis. A generic approach to cancer classification based on gene expression monitoring
by DNA microarrays is proposed and applied to two test cancer cases, colon and leukemia. The study attempts to analyze multiple
sets of genes simultaneously, for an overall global solution to the gene’s joint discriminative ability in assigning tumors
to known classes. With the workable concepts and methodologies described here an accurate classification of the type and seriousness
of cancer can be made. Using the orthogonal arrays for sampling and a search space reduction process, a computer program has
been written that can operate on a personal laptop computer. Both the colon cancer and the leukemia microarray data can be
classified 100% correctly without previous knowledge of their classes. The classification processes are automated after the
gene expression data being inputted. Instead of examining a single gene at a time, the DGL method can find the global optimum
solutions and construct a multi-subsets pyramidal hierarchy class predictor containing up to 23 gene subsets based on a given
microarray gene expression data collection within a period of several hours. An automatically derived class predictor makes
the reliable cancer classification and accurate tumor diagnosis in clinical practice possible.
- Content Type Journal Article
- Pages 1-19
- DOI 10.1007/s00500-010-0542-x
- Authors
- Dongguang Li, Edith Cowan University School of Computer and Security Science 2 Bradford Street Mount Lawley WA 6050 Australia